Martial netted twice in the second half to take the tie at Old Trafford away from West Ham, who had levelled through Ashley Fletcher following Ibrahimovic’s opener after two minutes. The Swede added the fourth deep into stoppage-time.
Southampton clinched their first appearance in the last four of the competition since 1987 with powerful first-half efforts from Jordy Clasie and Ryan Bertrand against a weakened Arsenal, who made 10 changes to their side.
United and Southampton will be joined in the semi-final draw by Liverpool, who beat Leeds United 2-0 on Tuesday, and Hull City.
(Reporting by Toby Davis; editing by Ed Osmond)
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